Borja NL, Daniel KL: Ramelteon for the treatment of insomnia.Pandi-Perumal SR, Srinivasan V, Spence DW, Moscovitch A, Hardeland R, Brown GM, Cardinali DP: Ramelteon: a review of its therapeutic potential in sleep disorders.Miyamoto M: Pharmacology of ramelteon, a selective MT1/MT2 receptor agonist: a novel therapeutic drug for sleep disorders.Karim A, Tolbert D, Cao C: Disposition kinetics and tolerance of escalating single doses of ramelteon, a high-affinity MT1 and MT2 melatonin receptor agonist indicated for treatment of insomnia.Vasoya, "Intermediates and processes for the synthesis of Ramelteon." U.S. Kingdom Organic compounds Super Class Benzenoids Class Indanes Sub Class Not Available Direct Parent Indanes Alternative Parents Coumarans / Alkyl aryl ethers / Secondary carboxylic acid amides / Oxacyclic compounds / Organopnictogen compounds / Organonitrogen compounds / Organic oxides / Hydrocarbon derivatives / Carbonyl compounds Substituents Alkyl aryl ether / Aromatic heteropolycyclic compound / Carbonyl group / Carboxamide group / Carboxylic acid derivative / Coumaran / Ether / Hydrocarbon derivative / Indane / Organic nitrogen compound Molecular Framework Aromatic heteropolycyclic compounds External Descriptors Not Available Affected organismsĬhemical Identifiers UNII 901AS54I69 CAS number 19 InChI Key YLXDSYKOBKBWJQ-LBPRGKRZSA-N References Synthesis Reference These are compounds containing an indane moiety, which consists of a cyclopentane fused to a benzene ring. Lake Erie Medical Dba Quality Care Produts LlcĬhemical Taxonomy Provided by Classyfire Description This compound belongs to the class of organic compounds known as indanes. Previous Next Brand Name Prescription Products Name The metabolism of Ramelteon can be decreased when combined with Acetaminophen. The metabolism of Acenocoumarol can be decreased when combined with Ramelteon. The metabolism of Abrocitinib can be decreased when combined with Ramelteon.Īceclofenac may decrease the excretion rate of Ramelteon which could result in a higher serum level.Īcemetacin may decrease the excretion rate of Ramelteon which could result in a higher serum level. The serum concentration of Ramelteon can be increased when it is combined with Abiraterone. The metabolism of Ramelteon can be increased when combined with Abatacept.
The serum concentration of Ramelteon can be increased when it is combined with Abametapir. Ramelteon may decrease the excretion rate of Abacavir which could result in a higher serum level. The risk or severity of adverse effects can be increased when Ramelteon is combined with 1,2-Benzodiazepine. Remelteon has no appreciable affinity for the gamma-aminobutyric acid (GABA) receptor complex or receptors that bind neuropeptides, cytokines, serotonin, dopamine, norepinephrine, acetylcholine, or opiates. While MT 1 and MT 2 receptors are associated with the sleep-wake cycle, MT 3 has a completely different profile, and therefore is not likely to be involved in the sleep-wake cycle. MT 1 receptors are believed to be responsible for regulation of sleepiness and facilitation of sleep onset, and MT 2 receptors are believed to mediate phase-shifting effects of melatonin on the circadian rhythm. Melatonin production is concurrent with nocturnal sleep, meaning that an increase in melatonin levels is related to the onset of self-reported sleepiness and an increase in sleep propensity. Ramelteon is a melatonin receptor agonist with both high affinity for melatonin MT 1 and MT 2 receptors, and lower selectivity for the MT 3 receptor. The metabolite also has weak affinity for the 5HT2b receptor. Ramelteon has an active metabolite that is less potent but circulates in higher concentrations than the parent compound. The MT 1 and MT 2 receptors are located in the brain's suprachiasmatic nuclei (SCN),which is known as the body's "master clock" because it regulates the 24-hour sleep-wake cycle. Ramelteon has a high affinity for the MT 1 and MT 2 receptors. It works by mimicking melatonin (MT), a naturally occuring hormone that is produced during the sleep period and thought to be responsible for the regulation of circadian rhythm underlying the normal sleep-wake cycle. Ramelteon is the first selective melatonin agonist.
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